Don’t mind me, I’m always seeking out these knowledge base articles in order to ensure my SharePoint environments run smoothly and to best practice. Part of that is making sure your Antivirus Software (whether it be Trend, Symantec, McAfee, etc.) plays nice.

SharePoint Exclusions

• http://support.microsoft.com/kb/952167

Take note of (BOTH) of the following sections:

• Folders that may have to be excluded from antivirus scanning for Microsoft SharePoint Foundation 2010
• Folders that may have to be excluded from antivirus scanning for SharePoint Server 2010

SQL Exclusions

In addition, the following document outlines recommended SQL Server exclusions:

http://support.microsoft.com/kb/309422/en-us